Acetylcholine

=__**Acetylcholine** __=

"20 things you don't know about me"
1. Where I hang out most of the time: Central Nervous System and the Peripheral Nervous System 2. I am responsible for: Learning, memory, mood changes and sending messages from motor nerves to muscles, mainly in the heart, bladder, and stomach where it generates muscle contractions. 3. I'm most similar to the drug: L Alpha Glycerylphosphorylcholine, also known as Alpha GPC 4. My favorite activity is: activating muscles in the peripheral nervous system and causing anti-excitatory actions in the central nervous system. 5. I hate it when: I am destroyed by the enzyme, acetylcholinesterase, because when this happens I am only effective for a short time. 6. The best thing about receptor sites is: When Acetylcholine and receptor sites are combined into a complex, it brings about a biophysical reaction, which results in the response from the receptive cell. Receptor sites exist in the membranes of the cells. 7. When humans don't have enough of me: brain functions slow down and therefore people are more likely to develop Alzheimer's Disease, when I decrease about 90% in the brain. 8. In a choice between robots or zombies: Zombies because robots don't have a heart or organs so i wouldn't be able to do my job. 9. The sucky thing about being a hormone: My job gets tiring after a while of sending mesages back and forth and i have to deal with mood changes. 10. A really strange fact about me: When I am a dominant trait in a person's body, they tend to be more sensory and socially oriented and creative with new ideas. Counselors, instructors, artists, writers, and actors have a high quantity of me. 11. My favorite food and why: I have many favorite foods including egg yolks, peanuts, fish, meat, and vegetables. These foods increase my production in the body. 12. I once dated a synapse, but it fell apart because: For the nerve signal to continue, I had to spread to another neuron or muscle cell to attach and activate a receptor protein. 13. Sleep is awesome because: During this time, I regulate and schedule REM sleep and form memories. 14. A neuron walks into a bar and says: I produce Acetylcholine in my spare time. 15. When humans have too much of me: it can produce feeling of paranoia that someone is taking advantage of you. 16. When and by who was I discovered?: I was the first neurotransmitter to be discovered by a German biologist named Otto Loewi in 1921. 17 . My best friends are: the enzyme choline acetyltransferase which is necessary for my synthesis. 18. What do I form from? choline and acetic acid to make C 7 H 16 NO 2 19. My enemies are: nicotine, physistigmine, curare, atropine 20. Another transmitter similar to me: Dopamine because we both turn the brain on and allow it to work hard and fast

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My molecular structure consists of many molecules, including acteic acid and choline. []

My molecules that are stored in vesicles are released into the synaptic gap and some of my molecules bind to nicotinic receptors, which are large proteins connected to the membrane of the muscle. []



This image shows my binding site in the receptor, and how I enter and bind to the receptor while the ions are entering it. []



This red-dotted line is my pathway in a brain affected by Alzheimer's Disease, which is when humans don't have enough of me in their body. []



In this image, this shows the process of transferring messages from a transmitting neuron to a receiving neuron where the receptors are located. I bind to these receptor sites. []

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